Is it true that tolerance and dependence equate to addiction?

Tolerance and dependence do not equate to addiction, making the assertion false. While tolerance refers to the body's diminishing response to a drug after its repeated use, and dependence involves experiencing withdrawal symptoms when the drug is not available, addiction encompasses a broader spectrum of behaviors. Addiction is characterized by compulsive drug-seeking behavior, continued use despite negative consequences, and a lack of control over drug use.

This distinction is crucial in pain management and opioid therapy, as many patients may develop tolerance and dependence as part of a legitimate treatment plan without developing an addiction. Recognizing this allows healthcare professionals to manage pain effectively while addressing safety concerns related to opioid use. It's essential to understand these concepts to prevent misunderstandings that can lead to stigma or improper treatment approaches for patients requiring pain management.